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Integrated Diabetes Services

Noninsulin medication use in type 1 diabetes


Use of insulin as the main therapy for type 1 diabetes is a no brainer – it is what is needed since the pancreatic beta cells aren’t making it.

However, use of other noninsulin medications such as metformin, GLP-1 receptor agonists, DPP-IV inhibitors, SGLT2 inhibitors and other noninsulin diabetes medications isn’t as common. While these medications were not developed specifically for type 1 diabetes, they could in fact play an important role in management. These medications are meant to assist with factors such as improved glycemic control, reduced insulin doses, promotion of weight loss and suppression of post meal glucose secretion – all people with diabetes can benefit from medications that help with each of these factors. 

However, according to a registry study that evaluated data from T1D Exchange (T1DX) registry in the US and the Prospective Diabetes Follow-up (DVP) registry in Germany and Austria, these medications are being used <5% of the time by those with type 1 diabetes.  And of all the medications available, the one most commonly used was metformin. This registry study also found that for the US patients there was a slightly lower A1C for those using these agents along with insulin compared to those on insulin therapy alone.

If you feel you have been struggling with diabetes management, have seen insulin needs and weight go up and seem to be unable to manage what happens in the aftermath of meals, give us a call at Integrated Diabetes Services.  We are happy to work with you for improved diabetes management, and will assist with defining whether or not an additional noninsulin medication may be in your best interest for improved management.  To schedule a visit give us a call at 610-642-6055. We look forward to working with you!

For further data and stats on the registry study see here: https://www.healio.com/endocrinology/diabetes/news/in-the-journals/%7B68662275-1fdd-4d0b-819b-b2bef6ff7c93%7D/5-of-us-patients-with-type-1-diabetes-use-adjuvant-noninsulin-agents

By |2017-09-18T21:52:02+00:00September 18th, 2017|Diabetes Bites, september 2017 Newsletter|2 Comments

About the Author:

Integrated Diabetes Services is the worldwide leader in one-on-one consulting for people who use insulin. Diabetes “coaching” services are available in-person and remotely via phone and the internet for children and adults.


  1. Joanne Sheridan December 8, 2017 at 8:51 am - Reply

    I would like to book a skype app please. I live on Ireland.My 13 year old daughter is type 1 for 2 years . Dx sept 2015. Her diabetes is not controlled. At present she is on 46iu tresiba each evening. Her carb ratio is 1:5. Her sensitivity is 1:2 . She uses novorapid flexpen. She takes metformin 500mg tablets three times a day. She is missing a lot of school due to the high blood sugars and anxiety. Her wt is 85kg. We try to bring her to the gym to a personal trainer wgich she enjoys. The gym makes her blood sugars go very high. She feels sick and unwell a lot of the time. She is also on Losec 20mg for her stomach. Thsnk you. Joanne Sheridan. I met you at the thrivabetes in Kildare last year

    • alicia downs December 18, 2017 at 2:24 pm - Reply

      Hi Joanne, We would be glad to schedule you. Please contact our office at 610-642-6055. Our office staff can assist you with scheduling and information for your initial consultation.

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